Adrafinil: effects on behavior
and cognition in aged canines

Siwak CT, Callahan H, Milgram NW.
Institute of Medical Science,
University of Toronto, Canada.
Prog Neuropsychopharmacol Biol Psychiatry 2000 Jul;24(5):709-26


1. Adrafmil is a novel vigilance promoting agent developed in France by Louis Lafon Laboratories. 2. Adrafinil causes increased locomotion without producing stereotypical activity in canines tested in an open field. 3. The effectiveness of a single treatment is long-lasting, and the effectiveness persists over repeated treatments. 4. Acquisition of a size discrimination problem is enhanced by adrafinil. This may be linked to performance motivation. 5. Adrafinil causes a long-lasting increase in high frequency electroencephalographic activity recorded from cortical electrodes. 6. These results indicate that adrafinil is novel behavioral stimulant with cognitive enhancing potential. The underlying mechanisms of action are still unknown.

Adrafinil: structure
Adrafinil and old dogs
Adrafinil and the mouse
Adrafinil and the monkey
Excessive daytime sleepiness

BLTC Research
Utopian Pharmacology
The Hedonistic Imperative

swan image
The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family